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Product Description | These antibodies were developed based on human p53 sequences (25-40 aa). It was tested to detect human p53 in human cell and tissue. | Western blot analysis of p53 in HeLa cell lysates with p53 antibody (ICP7110)A: 15 µg/mL crude protein B: 45 µg/mL crude protein | |
Species | Rabbit | ||
Formulation | 250 µg/mL in PBS, pH 7, with 50 % glycerol | ||
Immunogen | Human phosphor p53 peptide (15-40 aa) KLH conjugates | ||
Purification | Peptide-affinity chromatography | ||
Specificity | The antibody recognizes human p53 in cell and tissue. | ||
Species Tested | Mouse and human | ||
Applications | ELISA (1:2500); WB (1:2500) | ||
Scientific Description | P53 (tumour protein 53 or TP53) regulates the cell cycle by acting as a transcription factor. It suppresses tumours and hence it is often described as "the guardian of the genome", "the guardian angel gene", or the "master watchman". This refers to its role in conserving stability by preventing genome mutation. P53 refers to its molecular mass (53 kDa) on SDS-PAGE. | ||
Storage & Stability | Product is stable for several weeks at 4°C. For extended storage, store product at -20°C. Expiration date is one year from date of shipping if stored properly. | ||
Product Specific References | 1. Strachan T. et al. Human Molecular Genetics 2. Ch. 18, 1999 Cancer Genetics. |
加拿大ImmuneChem Pharmaceuticals, Inc. www.immunechem.comImmuneChem是一家由活跃在美国、加拿大生物科技前沿的华人科学家和留学生创建的。其核心技术及研发平台由加拿大ICP免疫公司和美国、加拿大数家拥有一流科学家和设备的实验室提供,并均已获得了技术持有人(公司)的授权。 主营产品公司提供以下产品: 1.细胞信号传导通路抗体,翻译后修饰抗体,细胞凋亡相关抗体,非放射性蛋白激酶测试盒,亲和填料; 2.磷酸化抗体,非磷酸化抗体,甲基化抗体,乙酰化