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Kit

Quantitative ELISA

Specific to dityrosine (tyrosine dimer).

All

96 wells

0.05 - 12 µmol/L

Urine

Competitive

Colorimetric

Manufactured by JaICA.

BLUE ICE

+4°C

+4°C

Do not freeze.

12 months after the day of manufacturing. See expiry date on ELISA Kit box.

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No

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Tyrosine is one of the major targets of protein oxidation. Dityrosine (DT) is known to be formed when tyrosine is damaged by free radicals, such as reactive oxygen species (ROS), metal-catalyzed oxidation, ultraviolet irradiation, and peroxidases. Dityrosine has been found in atherosclerotic lesions, and lipofuscin of pyramidal neurons of aged human brains. Dityrosine is a specific biomarker for protein oxidation. Dityrosine is reported to exist in various tissues and was also recently detected in urine samples. It is expected to be a novel protein oxdation marker, which is non-invasively detectable. Thie JaICA Dityrosine ELISA kit is designed for quantitative measurement of dityrosine especially in urine samples.Product References

Immunochemical detection of protein dityrosine in atherosclerotic lesion of apo-E-deficient mice using a novel monoclonal antibody: Y. Kato, et al.; BBRC 275, 11 (2000)